Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5593 | CA13854 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 74 |
| 2 | 3TC+AZT+SQV | 126 |
| 3 | D4T+NFV+NVP | 58 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | Y181C, G190GA | K20R, T69TN, E203EK, R211A, F214FL, D237E |
| >CA13854| codons 1-259 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIKELRQHLLAWGLTTPDKKHQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, L90M | G73S | L10I, K14R, K55R, I62V, L63P, A71V, I72X, I93L |
| >CA13922| codons 1-99 PQITLWQRPIVTIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFIRVRQYD QVPIEICGHKVXSTVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |