Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Gat-NR4 | agaNR4 | Japan | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | SQV | 36 |
| 3 | NFV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | T74P | L10I, R41K, I62V, L63P, A71V, V77I, I93L |
| >agaNR4| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QVPIEICGHKVIGPVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gatanaga, H | Anti-HIV effect of saquinavir combined with ritonavir is limited by previous long-term therapy with protease inhibitors. | ARHR, 1999 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |