<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5359 CA13723 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 99
2 3TC+AZT 13
3 3TC+AZT+RTV 56
4 3TC+D4T+NFV 13
5 3TC+DDC+DLV+NFV 26
6 3TC+D4T+DLV+IDV 25
7 3TC+D4T+DLV+RTV 34
8 None 13
9 3TC+APV+D4T+EFV 28

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M K43T L10I, E35D, M36I, I62V, L63P, A71V, T74S, I93L  
>CA13723| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDINLPGRWTPKLIGGIGGFVKVRQYD
QVPIEICGHKVIGSVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74IV, M184V, L210W, T215Y K219N L100I, K103N   E6D, T39E, E44D, V60I, V118I, I142V, Q174K, I178L, T200R, Q207E, H208Y, R211K, D218DE, K223KE, A272P, T286A, I293V, E297EQ  
>CA13861| codons 1-303
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPI
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDLVI
YQYVDDLYVGSDLEIGQHRRKIEELREYLWKWGFYTPENKHQEEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTQEAE
LEL

References
Author Title Citation
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005