Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1420 | CA13679 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 59 |
| 2 | DDC | 71 |
| 3 | D4T | 25 |
| 4 | D4T+ SQV | 6 |
| 5 | D4T+ 3TC+ SQV | 3 |
| 6 | D4T+ 3TC+ RTV+ NVP | 23 |
| 7 | D4T+ RTV+ 3TC+ IDV | 13 |
| 8 | D4T+ 3TC+ IDV | 40 |
| 9 | D4T+ NFV+ 3TC | 17 |
| 10 | D4T+ NFV+ 3TC+ SQV | 11 |
| 11 | D4T+ NFV | 6 |
| 12 | D4T+ NFV | 47 |
| 13 | DDI+ 3TC+ APV | 36 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | N348I | K103N, Y181C | K20R, K43N, E44ED, V118I, K122E, V179I, G196E, E204K, Q207E, R211K, A272P, I293V, E297A, I329L, M357T, G359S, A376S, T386I, A400T, V435A, G436GE, D460N, V467I, S468P, H483HY, L491S, E492K | N265NS, Q269QE |
| >CA13679| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVGSDLEIEQHRTKIEKLREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLSWASEIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKILKTGKYARTRSA HTNDVKQLTEAVQKISTESIVIWGKIPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAEAETFYVDGAANRETKLGKAGYVTNRGRQKVIPLTDTTNQKTELQ AIYLALQDSGSKVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L33F, G73S | L10I, E35D, M36L, N37D, I62V, L63P, C67F, A71V |
| >CA13764| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEDLDLPGRWKPKMIGGIGGFVKVRQYD QVPIEIFGHKVISTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |