<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
RTV-229 RTV229W16 U.S. 1994 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 RTV 16

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A   L10I, I13V, K14R, G16E, K20R, M36I, L63S, I64V, A71V  
>RTV229W16| codons 1-99
PQITLWQRPIVTVRIEGQLREALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYD
QISVEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF

References
Author Title Citation
Molla, A Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nat Med, 1996
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005