Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4360 | CA13644 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ SQV | 7 |
| 2 | D4T+ DDI+ IDV | 53 |
| 3 | D4T+ DDI+ IDV+ RTV | 57 |
| 4 | D4T+DDI+IDV+RTV+Unknown | 13 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73T | L10I, E35D, K43KN, L63P, I64V, I66IV, A71V, I72L, V77I, I85IV |
| >CA13644| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMNLPGRWNPKMIGGIGGFIKVRQYD QIPVEVCGHKVLTTVLIGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L210W, T215Y | D67DG | V60I, T69N, A98S, K101KQ, K122E, D123S, I135T, I142V, A158AS, S162A, V245VE | K13KQ, K22KT, T84TP |
| >CA13618| codons 1-269 PISPIETVPVKLQPGMDGPKVTQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKGSNRWRKLVDFRELNKRPQDFWEVQLGIPHPSGLQKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPSIFQASMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQ |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |