<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4360 CA13644 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ AZT+ SQV 7
2 D4T+ DDI+ IDV 53
3 D4T+ DDI+ IDV+ RTV 57
4 D4T+DDI+IDV+RTV+Unknown 13

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V, L90M G73T L10I, E35D, K43KN, L63P, I64V, I66IV, A71V, I72L, V77I, I85IV  
>CA13644| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMNLPGRWNPKMIGGIGGFIKVRQYD
QIPVEVCGHKVLTTVLIGPTPVNVVGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L210W, T215Y D67DG     V60I, T69N, A98S, K101KQ, K122E, D123S, I135T, I142V, A158AS, S162A, V245VE K13KQ, K22KT, T84TP
>CA13618| codons 1-269
PISPIETVPVKLQPGMDGPKVTQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKGSNRWRKLVDFRELNKRPQDFWEVQLGIPHPSGLQKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPSIFQASMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQ

References
Author Title Citation
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005