Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1829 | CA13622 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 41 |
| 2 | AZT+D4T+DDC | 52 |
| 3 | 3TC+D4T | 39 |
| 4 | 3TC+IDV | 32 |
| 5 | 3TC+DLV+NFV | 65 |
| 6 | ADV+IDV+NFV+SQV | 28 |
| 7 | ABC+ADV+IDV+NFV+SQV | 11 |
| 8 | ABC+ADV | 20 |
| 9 | None | 4 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | V32T | L10X, K20R, M36I, I62V, L63P, I64V, A71V, I72IV, P79PA |
| >CA13622| codons 1-99 PQITLWQRPXVTIKIGGQLREALLDTGADDTTLEEINLPGRWKPKIIGGIGGFIKVRQYD QVPVEICGHKVVGTVLVGATPVNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, L210W | A62V, D67E, T215C | Y181C | V108I | K20R, K122E, D177E, L228H, V245E, A272P, I293V, E297KR |
| >CA13591| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIKKKESTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFCTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |