Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1259 | CA13615 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 53 |
| 2 | AZT+DDC | 9 |
| 3 | D4T | 31 |
| 4 | 3TC+AZT | 42 |
| 5 | 3TC+AZT+IDV | 31 |
| 6 | 3TC+D4T+RTV+SQV | 49 |
| 7 | 3TC+D4T+EFV+NFV+SQV | 89 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215CY | K219N | L100I, K103N | E44D, V118I, K122E, D123E, D177E, I178M, H208Y, R211K, E248D, A272P, K277R, T286A, E297K |
| >CA13615| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFCTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54V, V82A, I84V | Q58E | L10I, L63C, H69HY, A71V, V77I, Q92K, I93L |
| >CA13627| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIVGIGGFVKVREYD QICIEICGYKVIGTVLIGPTPANVIGRNLLTKLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |