Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5450 | CA13597 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 35 |
| 2 | D4T+IDV | 95 |
| 3 | DDC+NVP+RTV+SQV | 18 |
| 4 | ABC+DDI | 57 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, T215F | D67S, K219Q | K20R, V60I, T69N, K103R, V118I, I135T, I142V, Q174R, V179I, G196E, E203D, R211K, F214L | T131TA, W252L, T253D, V254C, N255Q |
| >CA13597| codons 1-255 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKSSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSIPL DKDFRKYTAFAIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIII YQYMDDLYVGSDLEIEQHRTKIDELRQHLLKWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSLDCQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L90M | L10I, E35D, M36I, N37T, L63P, I64V, Q92K, I93L |
| >CA13628| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDITLPGRWKPKLIGGIGGFVKVRQYD QIPVEICGHKAIGTVLVGPTPVNIIGRNLMTKLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |