Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1543 | CA13596 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 208 |
| 2 | AZT+ DDC+ DDI+ NFV+ SQV | NA |
| 3 | D4T+ 3TC+ IDV+ NVP | 76 |
| 4 | D4T+ RTV+ SQV+ DDI+ ADV | 15 |
| 5 | D4T+ RTV+ SQV+ DDI+ ADV+ NFV | 3 |
| 6 | D4T+ SQV+ DDI+ ADV+ NFV | 13 |
| 7 | None | 3 |
| 8 | D4T+ SQV+ DDI+ NFV | 15 |
| 9 | None | 8 |
| 10 | D4T+3TC+IDV+RTV+EFV | 10 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | K219R | K43E, E44A, A98S, V118I, I135T, H208Y, R211E, L228H, V245L, A288S |
| >CA13596| codons 1-304 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLWEWGFYTPDRKHQKEPPFHWMGYELHPDKWT VQPILLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVIPLTEEAE LELA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I64V |
| >CA13005| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |