Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1116 | CA13563 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ AZT+ 3TC | 8 |
| 2 | IDV+ AZT+ 3TC | 21 |
| 3 | None | 53 |
| 4 | SQV+ RTV+ AZT+ 3TC | 2 |
| 5 | NFV+ DDI+ 3TC | 3 |
| 6 | SQV+ NFV+ DDI+ AZT | 34 |
| 7 | SQV+ DDI+ AZT+ 3TC | 14 |
| 8 | NRTI+ PI | 33 |
| 9 | SQV+ RTV+ IDV+ DDI+ D4T | NA |
| 10 | Unknown | 25 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, N37H, R41K, L63S |
| >CA13563| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMHLPGKWKPKMIGGIGGFIKVRQYD QISIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| R83K, V90I, K122E, G196E, R211K, A272P, V276T, K277R, L283LI, I293V, E297K |
| >CA13511| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLIRGTKALTEVVPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |