Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5508 | CA13541 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 39 |
| 2 | D4T+SQV | 21 |
| 3 | D4T+IDV+3TC | 26 |
| 4 | AZT+DDI+IDV | 21 |
| 5 | AZT+DDC+NFV+SQV | 17 |
| 6 | D4T+3TC+RTV+SQV | 13 |
| 7 | D4T+IDV+3TC+SQV | 82 |
| 8 | D4T+IDV+3TC+RTV | 21 |
| 9 | ABC+APV+DDI+RTV | 13 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10I, T12TA, L19I, L63P, I64V, A71V, I85V, I93L |
| >CA13541| codons 1-99 PQITLWQRPIVAIKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QIPVEICGHKVIGTVLVGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | K43E, K122E, I135V, K166R, E194EA, G196E, T200A, A272AS, T286A, E297K |
| >CA13656| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLAIEQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVIPLTKEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |