Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2256 | CA13530 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 29 |
| 2 | AZT+DDC | 78 |
| 3 | 3TC+AZT+SQV | 8 |
| 4 | AZT | 17 |
| 5 | 3TC+AZT+RTV | 9 |
| 6 | 3TC+AZT | 51 |
| 7 | D4T+IDV | 16 |
| 8 | D4T+IDV+RTV | 54 |
| 9 | D4T+DDI+RTV+SQV | 33 |
| 10 | D4T+DDI+EFV+RTV+SQV | 13 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | L100I, K103N | K11KR, V35VI, K43N, E44ED, R83K, V118VI, K122KE, G196E, T200A, Q207E, R211K, L228HR, V245E, A272P, K277R, Q278H, T286A | R72RG, D110DG |
| >CA13530| codons 1-286 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV FAIKKKDSTKWGKVVDFRELNKKTQDFWEVQLGIPHPAGIKKNKSVTVLGVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRAKIEELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, L90M | G73GS | L10I, I15V, K20M, M36I, N37D, I62IV, L63P, A71V, I85V, Q92QK |
| >CA13562| codons 1-99 PQITLWQRPIVTIKVGGQLMEALLDTGADDTVLEEIDLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVISTVLVGPTPTNIVGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |