<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Cab-l L47 Spain 1997 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC+AZT+DDI 104
2 3TC+D4T+RTV 36
3 3TC+D4T+RTV+SQV 56

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M L33F, F53L, T74P E34Q, N37H, R41K, I62V, L63P, I72L, G73V, V77I  
>L47| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVFQEMHLPGKWKPKIIGGIGGLIKVRQYD
QVPIEICGHKALVPVLIGPTPVNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, K70R, Y115F, Q151M, M184V V75I, F77L, F116Y, K219Q     K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228K  
>L47| codons 40-237
EMEEEGKISKIGPENPYNTPVFAIKRKDGIRWRKLIDLRELNKRTQDFWEVQLGIPHPAG
LKQKKSVTVLDVGDAFYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAI
FQSSMTRILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLGWGFTTPDQ
KHQKEPPFKWMGYELHPD

References
Author Title Citation
Cabana, M Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. J Med Virol, 1999
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005