Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Cab-l | L47 | Spain | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+DDI | 104 |
| 2 | 3TC+D4T+RTV | 36 |
| 3 | 3TC+D4T+RTV+SQV | 56 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Y115F, Q151M, M184V | V75I, F77L, F116Y, K219Q | K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228K |
| >L47| codons 40-237 EMEEEGKISKIGPENPYNTPVFAIKRKDGIRWRKLIDLRELNKRTQDFWEVQLGIPHPAG LKQKKSVTVLDVGDAFYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAI FQSSMTRILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLGWGFTTPDQ KHQKEPPFKWMGYELHPD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L33F, F53L, T74P | E34Q, N37H, R41K, I62V, L63P, I72L, G73V, V77I |
| >L47| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVFQEMHLPGKWKPKIIGGIGGLIKVRQYD QVPIEICGHKALVPVLIGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Cabana, M | Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. | J Med Virol, 1999 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |