Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Cab-l | L39 | Spain | 1995 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+DDI | 104 |
| 2 | 3TC+D4T+RTV | 36 |
| 3 | 3TC+D4T+RTV+SQV | 16 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Y115F, Q151M, M184V | V75I, F77L, F116Y | T39K, K43E, S68G, T69I, K102Q, K122E, K166R, T200A, R211G, L228Q |
| >L39| codons 39-238 KEMEEEGKISKIGPENPYNTPVFAIKRKDGIRWRKLIDLRELNKRTQDFWEVQLGIPHPA GLKQKKSVTVLDVGDAFYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPA IFQSSMTRILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLGWGFTTPD KKHQKEPPFQWMGYELHPDK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A, I84V | K43T | E34K, N37H, R41K, I62V, L63P, I72L |
| >L39| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLKEMHLPGKWTPKMIGGIGGFIKVRQYD QVPIEICGHKALGTVLVGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Cabana, M | Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. | J Med Virol, 1999 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |