Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Cab-k | K35 | Spain | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC+IDV | 36 |
| 2 | DDC+RTV+SQV | 48 |
| 3 | 3TC+D4T+RTV+SQV | 56 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, T12E, I15V, L19I, K20R, M36I, F53Y, I62V, L63S, A71V |
| >K35| codons 1-99 PQITLWQRPIVEIKVGGQIREALLDTGADDTVLEEINLPGRWKPKMIVGIGGYTKVRQYD QVSIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, Y115F, Q151M, M184V | K122E, I135T, S163C, D177N, G196E, I202V |
| >K35| codons 39-238 TEMEKEGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPA GLKKKKSVTVLDVGDAFFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPA IFQSCMTKILEPFRKQNPNIVIYQYVDDLYVGSDLEIEQHRTKVEELRQHLLRWGFTTPD KKHQKEPPFLWMGYELHPDK |
References
| Author | Title | Citation |
| Cabana, M | Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. | J Med Virol, 1999 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |