Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Cab-k | K24 | Spain | 1995 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC+IDV | 36 |
| 2 | DDC+RTV+SQV | 48 |
| 3 | 3TC+D4T+RTV+SQV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, T12E, I15V, L19I, K20R, M36I, I62V, L63S, I64V, A71V |
| >K24| codons 1-99 PQITLWQRPIVEIKVGGQIREALLDTGADDTVLEEINLPGRWKPKMIVGIGGFTKVRQYD QVSVEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M, M184V | T69N, K122E, I135T, S163C, D177N, G196E, I202V |
| >K24| codons 39-238 TEMEKEGKISKIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPA GLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPA IFQSCMTKILEPFRKQNPNIVIYQYVDDLYVGSDLEIEQHRTKVEELRQHLLRWGFTTPD KKHQKEPPFLWMGYELHPDK |
References
| Author | Title | Citation |
| Cabana, M | Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. | J Med Virol, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |