<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Cab-k K0 Spain 1994 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDC+IDV 36

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12E, I15V, M36I, L63A, I64V  
>K0| codons 1-99
PQITLWQRPLVEIKVGGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD
QIAVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        R83K, K122E, I135T, T165I, G196E, I202V R143I
>K0| codons 39-238
TEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPA
GLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIIYQYNVLPQGWKGSPA
IFQSSMIKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRTKVEELRQHLLRWGFTTPD
KKHQKEPPFLWMGYELHPDK

References
Author Title Citation
Cabana, M Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. J Med Virol, 1999
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005