Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Cab-I | I40 | Spain | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 56 |
| 2 | 3TC+AZT+DDI | 36 |
| 3 | IDV | 24 |
| 4 | 3TC+D4T+RTV+SQV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73T | L10I, Q18H, F53Y, L63P, V77I, I93L, C95F |
| >I40| codons 1-99 PQITLWQRPIVTIKIGGHLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGYIKVRQYD QIPIEICGHKAITTVLIGPTPVNVIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219Q | E40F, K43E, V60I, K122E, D123N, I135V, I178M, V179I, G196E, H208Y, R211K, D218E, L228H |
| >I40| codons 39-238 TFLEEEGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPA GLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPA IFQSSMTKILEPFRKQNPDMIIYQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPE QKHQKEPPFHWMGYELHPDK |
References
| Author | Title | Citation |
| Cabana, M | Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. | J Med Virol, 1999 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |