<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Cab-I I35 Spain 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI 56
2 3TC+AZT+DDI 36
3 IDV 24
4 3TC+D4T+RTV+SQV 8

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M G73S L10I, Q18H, L63P, V77I, I93L, C95F  
>I35| codons 1-99
PQITLWQRPIVTIKIGGHLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKAISTVLIGPTPVNVIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, V75M, M184V, L210W, T215Y K219Q     E44D, V60I, K122E, D123N, I135V, I178M, V179I, G196E, H208Y, R211K, D218E, L228H Y127H, W153C
>I35| codons 39-238
TELEKDGKISKIGPENPYNTPIFAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPA
GLKKKKSVTVLDVGDAYFSVPLDENFRKHTAFTIPSVNNETPGIRYQYNVLPQGCKGSPA
IFQSSMTKILEPFRKQNPDMIIYQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPE
QKHQKEPPFHWMGYELHPDK

References
Author Title Citation
Cabana, M Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. J Med Virol, 1999
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005