Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Cab-h | H60 | Spain | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 112 |
| 2 | 3TC+ AZT+ DDI | 40 |
| 3 | 3TC+ DDI+ IDV+ NVP | 52 |
| 4 | 3TC+ IDV+ NVP+ SQV | 16 |
| 5 | 3TC+ D4T+ IDV+ NVP+ RTV | 20 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K103N, Y181C | R83K, A98S, I135T, I142V, S162C, R211K, L228Q | I180T |
| >H60| codons 39-238 TELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKKTQDFWEVQLGIPHPS GLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPA IFQCSMTKILEPFRKQNPDIVTCQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPD KKHQKEPPFQWMGYELHPDK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48T, I54V, V82A | L24I | L10I, E35D, M36I, N37D, R41K, I64V, A71V, I72V, I93L |
| >H60| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEDIDLPGKWKPKLITGIGGFVKVRQYD QILVEICGHKVVGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Cabana, M | Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. | J Med Virol, 1999 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |