Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Cab-e | E37 | Spain | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 56 |
| 2 | 3TC+AZT+DDC | 48 |
| 3 | 3TC+AZT+IDV | 8 |
| 4 | 3TC+AZT+RTV | 28 |
| 5 | 3TC+D4T+RTV+SQV | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | E44D, K101Q, V118I, K122E, Q174R, N175Y, G196E, Q207E, R211K |
| >E37| codons 39-238 TELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPA GLQKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPA IFQSSMTKILEPFRKRYPDIVIYQYVDDLYVGSDLEIEQHRTKIEELREHLWKWGFYTPD KKHQKEPPFLWMGYELHPDK |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G73S | L10I, R41K, K43R, I62V, L63P, V77I, I93L | R87I |
| >E37| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWRPKMIGGIGGFIKVRQYD QVPIEICGHKAISTVLIGPTPVNIIGINLLTQLGCTLNF |
References
| Author | Title | Citation |
| Cabana, M | Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. | J Med Virol, 1999 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |