Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Cab-b | B58 | Spain | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 112 |
| 2 | 3TC+AZT+DDC | 17 |
| 3 | 3TC+AZT+DDC+IDV | 40 |
| 4 | 3TC+D4T+RTV+SQV | 96 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, I84V | L10I, I13V, K14R, L63P, L89I |
| >B58| codons 1-99 PQITLWQRPIVTVRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKAIGTVVVGPTPVNVIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | D67E, F77L | E40F, K43E, S68G, V118I, K122P, D123E, I135T, S162C, D177E, Q207E, R211K | L149I |
| >B58| codons 39-238 TFLEEEGKISKIGPENPYNTPVFAIKKKEGTKWRKLMDLRELNKRTQDFWEVQLGIPHPA GLKKKKSVTVLDVGDAYFSIPLDPEFRKYTAFTIPSTNNETPGIRYQYNVIPQGWKGSPA IFQCSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPD KKHQKEPPFLWMGYELHPDK |
References
| Author | Title | Citation |
| Cabana, M | Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. | J Med Virol, 1999 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |