Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Cab-a | A18 | Spain | 1997 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT+D4T+SQV | NA |
2 | 3TC+D4T+IDV | 48 |
3 | DDI+NVP+RTV | 17 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, D67N, M184V, L210W, T215Y | Y181C | K43E, E44D, K49R, V106I, V118I, K122E, I135L, D177N, G196E |
>A18| codons 39-238 TELEEDGKISRIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPA GLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPA IFQSSMTKILEPFRKQNPNIVICQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPD KKHQKEPPFLWMGYELHPDK |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
V82A, L90M | G73S | L10I, K20R, E35D, M36I, D60E, I62V, L63P, H69K, A71V, I72V |
>A18| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYE QVPIEICGKKVVSTVLVGPTPANIIGRNLMTQIGCTLNF |
References
Author | Title | Citation |
Cabana, M | Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors. | J Med Virol, 1999 |
Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |