Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4165 | CA13322 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 4 |
| 2 | None | 22 |
| 3 | 3TC+AZT+IDV | 43 |
| 4 | 3TC+D4T | 67 |
| 5 | DDC+DDI+NFV | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | L10F, N88D | I3IN, T12S, I13X, L19Q, L63P, A71T, V77I |
| >CA13322| codons 1-99 PQNTLWQRPFVSXKIGGQQKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTIGTVLIGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, T215Y | V75S | V35I, V118I, K122E, S134SR, I135T, D177E, T200A, F214L, T286A, E291D | I132IR, E138EV |
| >CA12935| codons 1-292 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVSDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTRPRTNNVTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGLYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDV |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |