Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5423 | CA13319 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 61 |
| 2 | D4T+DDC | 57 |
| 3 | 3TC+D4T+SQV | 17 |
| 4 | 3TC+D4T+RTV | 61 |
| 5 | D4T+NVP+SQV | 78 |
| 6 | 3TC+D4T+RTV | 32 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82F, L90LM | F53FL | T4TN, K14KR, I15IV, R41K, D60E, L63P, V75VI |
| >CA13319| codons 1-99 PQINLWQRPLVTIRVGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGLIKVRQYE QIPIEICGHKAIGTILVGPTPFNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K11KQ, D17DG, I31IV, W88C, D121H, K122E, I135T, D177E, R211K | W24WG |
| >CA13157| codons 1-254 PISPIETVPVQLKPGMGGPKVKQGPLTEEKVKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTV |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |