Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1125 | CA13317 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 208 |
| 2 | DDC | 52 |
| 3 | DDI | 91 |
| 4 | AZT+ 3TC | 52 |
| 5 | RTV+ DDC+ D4T | 8 |
| 6 | IDV+ DDC+ D4T | 12 |
| 7 | None | 29 |
| 8 | IDV+ AZT+ 3TC | 21 |
| 9 | AZT+ 3TC+ SQV | 90 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10LI, I13V, E35D, R41K, D60E, L63P, A71V |
| >CA13317| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEDMNLPGKWKPKMIGGIGGFIKVRQYE QIPIEICGHKVIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, T215F | K219Q | T39A, V60I, A98S, K101I, D123E, S162Y, D177N, V179I, G196E, Q207E, D218E, L228H, V245E, A272P, K277R, A288S, E291D, I293V, E297T |
| >CA13155| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLIKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPNIII YQYVDDLYVGSDLEIEQHRTKIEELREHLLRWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTDVVPLTTEAE LEL |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |