Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5359 | CA13246 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 99 |
| 2 | 3TC+AZT | 13 |
| 3 | 3TC+AZT+RTV | 56 |
| 4 | 3TC+D4T+NFV | 13 |
| 5 | 3TC+DDC+DLV+NFV | 26 |
| 6 | 3TC+D4T+DLV+IDV | 25 |
| 7 | 3TC+D4T+DLV+RTV | 34 |
| 8 | None | 13 |
| 9 | 3TC+APV+D4T+EFV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | K43T | L10I, I15IL, K20KT, A22AV, E35D, M36I, I62V, L63P, A71V, T74S, I93L |
| >CA13246| codons 1-99 PQITLWQRPIVTIKLGGQLTEVLLDTGADDTVLEDINLPGRWTPKLIGGIGGFVKVRQYD QVPIEICGHKVIGSVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | L100LI, K103N | E6D, T39E, E44D, V60I, V118I, I142V, Q174K, I178L, T200R, E203EK, Q207E, H208Y, R211K, K223E, A272P, T286A, I293V, E297EQ | K281K* |
| >CA13083| codons 1-302 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDLVI YQYVDDLYVGSDLEIGQHRRKIKELREYLWKWGFYTPDNKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLC*LLRGAKALTEVVPLTQEAE LE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |