Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5350 | CA13235 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 213 |
| 2 | DDI | 91 |
| 3 | D4T | 61 |
| 4 | AZT+DDC+IDV | 60 |
| 5 | 3TC+AZT+IDV | 17 |
| 6 | 3TC+D4T+NVP | 47 |
| 7 | ABC+RTV+SQV | 22 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82T, L90M | G73GS | L10V, I13V, I15V, K45R, I62V, L63P, A71V |
| >CA13235| codons 1-99 PQITLWQRPVVTVKVGGQLKEALLDTGADDTVLEEMNLPGRWKPRMIGGIGGFIKVRQYD QVPIEICGHKVISTVLVGPTPTNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215F | K219Q | K20KR, T27TS, V35T, T39A, V60I, T69TN, K122E, I135T, T139M, G196E, E203EG, H221HL | R72RG |
| >CA13071| codons 1-253 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALTEICAELEKEGKISKIGPENPYNTPI FAIKKKNSNRWGKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIGELRQHLLRWGFFTPDQKLQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWT |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |