Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1492 | CA13222 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 74 |
| 2 | DDC+DDI | 61 |
| 3 | AZT+DDC | 31 |
| 4 | DDC | 104 |
| 5 | 3TC+D4T | 48 |
| 6 | 3TC+NVP | 4 |
| 7 | EFV+IDV | 22 |
| 8 | 3TC+AZT+EFV+IDV | 51 |
| 9 | D4T+DDI+NFV+SQV | 33 |
| 10 | D4T+DDI+NFV | 41 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | T74P | I15V, K43R, Q61E, I62V, L63P, I72V, I93L | R8RG, D25DV, A28AP |
| >CA13222| codons 1-99 PQITLWQGPLVTIKVGGQLKEALLVTGPDDTVLEEMNLPGRWRPKIIGGIGGFIKVRQYD EVPIEICGHKAVGPVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | K103KN | K20R, K49KR, K122E, K126KR, I135IL, D177G, Q207E, R211K, A272P, Q278QH, T286TA | N137S, E138E* |
| >CA13061| codons 1-290 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRRYTAFTIPSLNS*TPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGAKALT |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. | AAC, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |