Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
CA798 | CA13183 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | NRTI | 291 |
2 | AZT+DDC+SQV | 26 |
3 | None | 65 |
4 | 3TC+AZT+IDV | 105 |
5 | ADV+DDI+EFV | 29 |
6 | DDI+EFV | 3 |
7 | None | 17 |
8 | ABC+ADV+IDV+RTV | 10 |
9 | 3TC+ADV+D4T+IDV+RTV | 5 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
I54V, V82F, L90M | G73C | L10I, I13IV, I15V, K20I, E35D, M36I, R57K, Q61N, I62V, L63C, T74S |
>CA13183| codons 1-99 PQITLWQRPIVTVKVGGQLIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVKQYD NVCIEICGHKAICSVLVGPTPFNIIGRNLMTQIGCTLNF |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, M184V, L210W, T215Y | V21I, K43E, K82KR, K122E, S134SG, I142IL, D177E, T200A, R211K, A272P, T286A, I293V | R143RG |
>CA13024| codons 1-300 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNRRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPGINNETPGLGYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE |
References
Author | Title | Citation |
Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |