Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA798 | CA13183 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | 291 |
| 2 | AZT+DDC+SQV | 26 |
| 3 | None | 65 |
| 4 | 3TC+AZT+IDV | 105 |
| 5 | ADV+DDI+EFV | 29 |
| 6 | DDI+EFV | 3 |
| 7 | None | 17 |
| 8 | ABC+ADV+IDV+RTV | 10 |
| 9 | 3TC+ADV+D4T+IDV+RTV | 5 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F, L90M | G73C | L10I, I13IV, I15V, K20I, E35D, M36I, R57K, Q61N, I62V, L63C, T74S |
| >CA13183| codons 1-99 PQITLWQRPIVTVKVGGQLIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVKQYD NVCIEICGHKAICSVLVGPTPFNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | V21I, K43E, K82KR, K122E, S134SG, I142IL, D177E, T200A, R211K, A272P, T286A, I293V | R143RG |
| >CA13024| codons 1-300 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNRRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPGINNETPGLGYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |