<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA798 CA13183 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 NRTI 291
2 AZT+DDC+SQV 26
3 None 65
4 3TC+AZT+IDV 105
5 ADV+DDI+EFV 29
6 DDI+EFV 3
7 None 17
8 ABC+ADV+IDV+RTV 10
9 3TC+ADV+D4T+IDV+RTV 5

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82F, L90M G73C L10I, I13IV, I15V, K20I, E35D, M36I, R57K, Q61N, I62V, L63C, T74S  
>CA13183| codons 1-99
PQITLWQRPIVTVKVGGQLIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVKQYD
NVCIEICGHKAICSVLVGPTPFNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y       V21I, K43E, K82KR, K122E, S134SG, I142IL, D177E, T200A, R211K, A272P, T286A, I293V R143RG
>CA13024| codons 1-300
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNRRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPGINNETPGLGYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE

References
Author Title Citation
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005