Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1535 | CA13105 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 104 |
| 2 | AZT | 39 |
| 3 | 3TC+AZT | 39 |
| 4 | 3TC+D4T+NFV | 43 |
| 5 | DDC+DLV+RTV+SQV | 57 |
| 6 | 3TC+DDI+NFV | 44 |
| 7 | ABC+APV+EFV | 21 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, M184V | K219E | K103N, Y181C | V108I, P225H | S68G, K101Q, I135T, S162A, R211K, L228H, V245E, A272P, V276I, K277R, K281KR, L283I, E297A | A299AG |
| >CA13105| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDEKHQKEHPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKIRQLCRLIRGTKALTEVIPLTAEGE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50V | L10I, I13V, I15V, I64V, A71AV |
| >CA13267| codons 1-99 PQITLWQRPIVTVKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGVGGFIKVRQYD QILVEICGHKVIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |