Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5354 | CA13077 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | 3TC+ AZT | 104 |
| 3 | 3TC+ AZT+ IDV | 34 |
| 4 | D4T+ DDI+ RTV+ SQV | 17 |
| 5 | AZT+ D4T+ NVP | 52 |
| 6 | D4T+ DDI+ EFV+ IDV+ RTV | 4 |
| 7 | D4T+ DDI+ EFV+ IDV | 40 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | V106A, G190A | F227L | E44D, V60I, W88C, V118I, K122E, I135M, I178M, I195L, G196E, E203K, H208Y, R211K, K223E, V245E, A272P, K277R, E297K | V292VG |
| >CA13077| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFCEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVASDLELEQHRTKIKELRQYLWKWGFYTPDKKHQEEPPLLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEGIPLTKEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | V32T, L33F | L10I, I13V, I15IV, M36MI, I64V, A71V | R8RG |
| >CA13265| codons 1-99 PQITLWQRPIVTVKVGGQLKEALLDTGADDTTFEEINLPGRWKPKIIGGIGGFIKVRQYD QILVEICGHKVIGTVLVGPTPVNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |