<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA799 CA13068 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 261
2 DDI 65
3 AZT+DDI 52
4 3TC+AZT 48
5 D4T+DDC+RTV 31
6 D4T+DDC+IDV 13
7 3TC+AZT+RTV+SQV 13
8 D4T+NFV+NVP 9
9 3TC+AZT+D4T+IDV 14
10 3TC+AZT+DDI+RTV+SQV 27
11 3TC+AZT+IDV+RTV 8
12 3TC+ABC+AZT+Unknown 39
13 ABC+LPV+TDF 6

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, V75M, M184V, L210W, T215Y D67E K103N, Y181I A98G V35M, K43Q, E44D, S68G, K122E, I135T, D177E, V179I, G196E, E203K, Q207E, H221HY, V245VM, A272P, V276I, Q278QE, A288S, I293V, E297K, A304G R72RG, A299AG
>CA13068| codons 1-304
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV
FAIKKKEGTKWGKLMDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII
IQYVDDLYVGSDLEIEQHRTKIKELREHLWRWGFYTPDKKYQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKELCKLLRGTKSLTEVVPLTKEGE
LELG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M G73S L10I, I15V, K20IM, E35D, M36I, R57K, I62V, L63P, A71V  
>CA13231| codons 1-99
PQITLWQRPIVTIKVGGQLIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVKQYD
QVPIEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005