Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1524 | CA13062 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 17 |
| 2 | AZT+DDI | 13 |
| 3 | None | 122 |
| 4 | 3TC+AZT | 35 |
| 5 | 3TC+D4T | 78 |
| 6 | 3TC+D4T+SQV | 20 |
| 7 | 3TC+D4T+RTV+SQV | 71 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | F77L | E138K | V35T, T39A, E44ED, V60I, V118I, K122E, I135T, S162X, H208HY, R211RK, A272P, K277R, T286A |
| >CA13062| codons 1-291 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNKTPGIRYQYNVLPQGWKGSPAIFQXSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, V82A, I84V | L10I, I13V, E35D, M36I, N37D, L63P, A71V, T74S |
| >CA13223| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEDIDLPGRWKPKMIVGIGGFIKVRQYD QIPIEICGHKVIGSVLVGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |