Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 8261 | 8261 | Malawi | 2007 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Q151M | A62V, V75I, F116Y, K219E | V106M, Y188C | T39E, S48T, S68G, A98S, K122E, T139TA, A158S, K173A, Q174K, D177E, I178M, G196T, T200A, I202V, Q207K, H208HY, H221Y, E224D, P243PT, V245Q |
| >8261| codons 38-247 CEEMEKEGKITKIGPENPYNTPVFVIKRKDGTRWRKLIDFRELNKRTQDFWEVQLGIPHP SGLKKKKSMTVLDVGDAYYSVPLDEDFRKYTAFTIPSINNEAPGIRYQYNVLPMGWKGSP SIFQSSMTKILEPFRAKNPEMVIYQYMDDLCVGSDLEITQHRAKVEELRKYLLRWGFTTP DEKYQKDPPFLWMGYELHPDKWTVQTIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, L19I, M36I, N37D, R41K, H69K, L89M, I93L |
| >8261| codons 4-99 TLWQRPLVTIKVGGQIKEALLDTGADDTVLEEIDLPGKWKPKMIGGIGGFIKVRQYDQIL IEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Hosseinipour, MC | The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy. | AIDS, 2009 |