Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 8503 | 8503 | Malawi | 2006 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, T69~ | K219R | K101E, Y181C, G190A | T39E, S48T, V60I, S68G, K122E, D123S, E138A, K173A, D177E, T200A, I202V, E204K, Q207A, L210S, R211K, F214L, H221Y, V245Q | P157A |
| >8503| codons 38-247 CEEMEKEGKITKIGPENPYNTPIFAIKRKDG~KWRKLVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSVPLDESFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSA AIFQSSMTKILEPFRAQNPEIVICQYMDDLYVASDLEIGQHRAKVEKLRAHLSKWGLTTP DRKYQKEPPFLWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, E35D, M36I, N37E, D60E, L63P, H69K, L89M, I93L |
| >8503| codons 4-99 TLWQRPLVSIKVGGQIKEALLDTGADDTVLEDIELPGRWKPKMIGGIGGFIKVRQYEQIP IEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Hosseinipour, MC | The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy. | AIDS, 2009 |