<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
8983 8983 Malawi 2006 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74I, M184V, L210W, T215Y   K103N A98G, V108I T39E, E44D, S48T, S68SG, V118I, K122E, D123S, I135L, E138EG, I142T, K173AE, Q174R, D177E, I178M, G196D, T200A, E203K, Q207E, R211K, H221Y, V245Q  
>8983| codons 38-247
CEELEKDGKITKIGPENPYNTPVFAIKKKDGTKWRKIVDFRELNKRTQDFWEVQLGIPHP
GGLKKNKSVTILDVGDAYFSIPLDESFRKYTAFTIPSLNNGTPGTRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRERNPEMVIYQYVDDLYVGSDLEIDQHRAKIKELREHLWKWGFYTP
DKKYQKEPPFLWMGYELHPDKWTVQPIQLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, L19I, M36I, R41K, D60E, Q61E, L63P, H69K, L89M, I93L  
>8983| codons 4-99
TLWQRPLVSIKIGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYEEIP
IEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Hosseinipour, MC The public health approach to identify antiretroviral therapy failure: High-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy. AIDS, 2009