<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
8947 8947 Malawi 2006 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
Q151M, T215Y A62V, V75I, F77L, F116Y, K219Q K103N, Y181C   T39D, S48T, S68G, T69TN, V111I, V118I, K122E, D123N, I142V, M164L, T165I, K173A, T200A, I202IV, Q207E, R211K, F214FL, V245Q  
>8947| codons 38-247
CDEMEKEGKITKIGPENPYNTPVFVIKKKDGNKWRKLIDLRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTVLDIGDAYYSIPLDENFRKYTAFTIPSINNETPGVRYQYNVLPMGWKGSP
AIFQSSLIKILEPFRAQNPDIVICQYMDDLYVGSDLEIGQHRAKVEELREHLLKWGLYTP
DQKHQKEPPFLWMGYELHPDKWTVQPIQLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N L10F, L33F, N88D T12S, I15V, L19I, K20T, E35D, M36I, Q61E, L63T, H69K, T74S, L89M, I93L  
>8947| codons 4-99
TLWQRPFVSIKVGGQITEALLDTGADNTVFEDINLPGRWKPKMIGGIGGFIKVRQYDEIT
IEICGKKAIGSVLVGPTPVNIIGRDMLTQLGCTLNF

References
Author Title Citation
Hosseinipour, MC The public health approach to identify antiretroviral therapy failure: High-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy. AIDS, 2009