Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5289 | CA12992 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NFV | 35 |
| 2 | D4T+DDI+NVP | 39 |
| 3 | ABC+RTV+SQV | 29 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84IV, L90M | K43T | L10V, I13V, K14R, K20KT, E35D, M36I, I62V, L63P, I64V, T74S |
| >CA12992| codons 1-99 PQITLWQRPVVTVRIGGQLTEALLDTGADDTVLEDINLPGRWTPKMIGGIGGFIKVRQYD QVPVEICGHKAIGSVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | Y181C | S3X, K20R, V21I, E44D, A98S, I135T, K154KE, K166R, Q197E, R211K, H221HY, K277R, Q278H, I293V |
| >CA12955| codons 1-298 PIXPIETVPVKLKPGMDGPRIKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWEGSPAIFQSSMTRILEPFRKQNPDIVI CQYMDDLYVGSDLEIGEHRTKIEELRQHLLKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGTKALTEVVPLTEE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |