Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5291 | CA12981 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 18 |
| 2 | DDI | 26 |
| 3 | D4T | 78 |
| 4 | 3TC+D4T | 26 |
| 5 | 3TC+D4T+IDV | 135 |
| 6 | 3TC+D4T+NFV | 38 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | I13IV, M36MI, N37S, I62V, L63P, V77I, I93L |
| >CA12981| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADNTVLEEISLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, L210W, T215Y | K122E, I135IM, I142V, S162C, G196E, Q207E, R211K, V245X, A272P, K277R, I293V, E297A | A299AG |
| >CA12958| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSMNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIXLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEGE LE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |