Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5299 | CA12980 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NVP | 52 |
| 2 | ABC+APV+D4T | 72 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V | Q58QE | I13V, I15V, L19I, E35D, N37S, R41K, L63P, A71T, I72V, I93L |
| >CA12980| codons 1-99 PQITLWQRPLVTVKVGGQIKEALLDTGADDTILEDMSLPGKWKPKMVGGIGGFIKVREYD QIPIEICGHKTVGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219E | Y188YH | S68SG, D123E, I142V, S162N, Q197QH, T200A, R206RG, R211S, D218DA, E248D | L234LP |
| >CA13595| codons 1-252 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYMDDLHVGSDLEIGHHRAKIEELGQHLLSWGFFTPAEKHQKEPPFLWMGYEPHPDKWT VQPIVLPDKDSW |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |