Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1175 | CA12975 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ NFV+ 3TC | 39 |
| 2 | AZT+ DDC+ IDV | 14 |
| 3 | None | 4 |
| 4 | AZT+ DDC | 4 |
| 5 | DDC+ RTV+ SQV+ AZT | 74 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, N37D, L63P, A71T |
| >CA12975| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35I, K102R, D121H, K122E, S162C, E169D, D177E, T200A, Q207QP, R211K, K263KR, A272P, K281R, I293V, E297K | E138EV, T253TS |
| >CA12926| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSINNVTPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELRPHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWSVNDIQKLVGRLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTKEAE L |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |