Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4303 | CA12924 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 52 |
| 2 | DDI | 48 |
| 3 | 3TC+AZT | 18 |
| 4 | 3TC+AZT+IDV | 168 |
| 5 | ABC+D4T+EFV | 19 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LI, M184V, L210W, T215Y | K103N | V108I | K20R, I135T, K173E, Q174K, D177E, Q197E, I202V, Q207R, R211K, A272P, R284K, T286A, I293V, E297K, A304G |
| >CA12924| codons 1-304 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREKNPEIVI YQYVDDLYVGSDLEIGEHRTKVEELRRHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVVPLTKEAE LELG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10I, I15V, K20R, E35D, M36I, N37D, R57K, I62V, L63P, A71V, I85V, I93L |
| >CA12973| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVKVKQYD QVPIEICGHKVIGTVLVGPTPANIVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |