Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4334 | CA12916 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 26 |
| 2 | 3TC+D4T+IDV | 52 |
| 3 | DDI+DLV+RTV+SQV | 52 |
| 4 | D4T+ADV+EFV+RTV+SQV | 21 |
| 5 | None | 26 |
| 6 | ABC+D4T+APV+NFV | 21 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90LM | L33LI | L10LI, L19LI, K20X, E35D, M36MI, N37D, L63P, A71IT, Q92QK |
| >CA12916| codons 1-99 PQITLWQRPIVTIKIGGQIXEALLDTGADDTVIEDIDLPGRWKPKMIGGIGGFVKVRQYD QIPIEICGHKIIGTVLVGPTPVNVIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74V, L210W, T215Y | K219N | Y181C, G190GA | V179D | T39E, R83K, K103R, K122E, S162C, G196GE, E203D, R211K, V245Q, A272AP, T286A, V292I |
| >CA12834| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIDI CQYMDDLYVASDLEIEQHRTKIDELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIIPLTEEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |