Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5257 | CA12897 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 87 |
| 2 | 3TC+AZT+IDV | 70 |
| 3 | D4T+RTV | 22 |
| 4 | D4T+DDI+NVP | 26 |
| 5 | 3TC+D4T+DDI+NFV | 48 |
| 6 | ABC+APV | 25 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24LI, K43KT | L10V, E35D, M36MI, L63P, I64V, T74S |
| >CA12897| codons 1-99 PQITLWQRPVVTIKIGGQLKEALIDTGADDTVLEDINLPGRWTPKLIGGIGGFVKVRQYD QIPVEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184MV, L210W, T215Y | V35I, E44D, K122E, E169D, E203K, Q207E, R211K, K223E, T286A, I293V |
| >CA12853| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |