<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
TC-68 TC68_2004 Zimbabwe 2004 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP 61
2 3TC+AZT+NFV 13
3 3TC+AZT+LPV 4

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54L, L90LM L10LF I15V, L19I, K20T, E35DG, M36I, N37S, R41K, I64L, H69K, V82I, I85V, L89M, I93L  
>TC68_2004| codons 1-99
PQITLWQRPFVTIKVGGQITEALLDTGADDTVLEGISLPGKWKPKMIGGIGGFLKVRQYD
QILLEICGKKAIGTVLVGPTPINIVGRNMMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       K22R, I31L, V35T, E36A, T39E, E40D, S48T, T69A, W88C, K122E, D123S, S162H, K173A, D177E, E203Q, Q207E, R211K  
>TC68_2004| codons 1-239
PISPIETVPVKLKPGMDGPKVRQWPLTEEKLKALTAICEDMEKEGKITKIGPENPYNTPV
FAIKKKDSAKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQHSMTKILEPFRAQNPEIVI
YQYVDDLYVGSDLEIGQHRTKIQELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKW

References
Author Title Citation
Kassaye, S Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy. JAIDS, 2009