Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TCDD-30 | TC30_2003 | Zimbabwe | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ NFV+ 3TC | 4 |
| 2 | 3TC+ AZT+ IDV | 95 |
| 3 | NVP+ 3TC+ D4T | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V | L10I, T12A, I15V, L19I, K20KR, E35D, M36I, R41K, L63P, H69Q, L89M, I93L |
| >TC30_2003| codons 1-99 PQITLWQRPIVAIKVGGQIREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVRQYD QIPIEICGQKAIGTVLVGPTPVNVIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | Y181C | V35T, T39E, S48T, E53D, V60I, K122E, D123S, K173T, D177E, I178L, T200A, Q207A, R211K, L228R, V245Q |
| >TC30_2003| codons 1-253 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKEGKITKIGPDNPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPELVI CQYMDDLYVGSDLEIGQHRAKIEELRAHLLKWGFFTPDQKHQKEPPFRWMGYELHPDKWT VQPIQLPEKDSWT |
References
| Author | Title | Citation |
| Kassaye, S | Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy. | JAIDS, 2009 |
| Johnston, E | High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. | J Virol, 2003 |