Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TCDD-31 | TC31_2003 | Zimbabwe | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC+ SQV | 43 |
| 2 | APV+ NVP+ DDI | 130 |
| 3 | EFV+ IDV+ LPV | 25 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, T215Y | K103N, Y181C, G190A | S3C, E6D, V35T, T39E, K122E, D123S, I142V, S163I, T165L, K173T, Q174K, D177E, T200A, E203D, Q207E, H208Y, R211K, V245Q, E248D |
| >TC31_2003| codons 1-253 PICPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSIMLKILEPFRTKNPEIVI CQYMDDLYVASDLEIGQHRAKIDELREYLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, L76V | V32VG, I47IM | D60DE, L63P, H69K, T74A, I85V, L89M, I93L | R41R*K |
| >TC31_2003| codons 29-99 DDTGLEEMNLPGKWKPKIMGGIGGFIKVRQYEQIPIEICGKKAIGAVVVGPTPVNIVGRN MLTQLGCTLNF |
References
| Author | Title | Citation |
| Kassaye, S | Envelope coreceptor tropism, drug resistance, and viral evolution among subtype C HIV-1-infected individuals receiving nonsuppressive antiretroviral therapy. | JAIDS, 2009 |
| Johnston, E | High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment. | J Virol, 2003 |